Table II

Plasma proteins detected in at least two datasets

The table presents a nonredundant list of 195 proteins found in at least two of the four input data sources, alphabetized by protein description (containing name and synonyms). Entries found in all four data sources are shown in bold. Lit, 2DEMS, LCMS1, and LCMS2 columns give the number of accessions in each original data set that were assigned to each NR entry. These are summed across the data sources to yield Total_accessions. Total_sources summarizes the number of sources (here ranging from 2 to 4) in which the entry was found. Signal provides one of four possible values resulting from the signal sequence prediction procedure. TM gives the predicted number of transmembrane segments in the protein.

P10809101133No060-kDa heat shock protein, mitochondrial precursor (Hsp60) (60-kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (mitochondrial matrix protein P1) (P60 lymphocyte protein) (hucha60)
AAB27045001122Possible signal070-kDa peroxisomal membrance protein homolog (internal fragment)
P02570240283No0Actin, cytoplasmic 1 (β-actin)
Q15848110022Signal confident0Adiponectin precursor (30-kDa adipocyte complement-related protein) (ACRP30) (adipose most abundant gene transcript 1) (apm-1) (gelatin-binding protein)
NP_001124011022Signal confident0Afamin precursor; α-albumin (Homo sapiens)
P02763111033Signal confident0α-1-acid glycoprotein 1 precursor (AGP 1) (orosomucoid 1) (OMD 1)
P01011112043Signal confident0α-1-antichymotrypsin precursor (ACT)
P01009 1 1 1 1 4 4 Signal confident 0 α-1-antitrypsin precursor (α-1 protease inhibitor) (α-1-antiproteinase) (PRO0684/PRO2209)
P04217111033No0α-1B-glycoprotein precursor (α-1-B glycoprotein)
P08697 1 1 1 1 4 4 Signal 0 α-2-antiplasmin precursor (α-2-plasmin inhibitor) (α-2-PI) (α-2-AP)
P02765 1 1 1 1 4 4 Signal confident 0 α-2-HS-glycoprotein precursor (Fetuin-A) (α-2-Z-globulin) (Ba-α-2-glycoprotein) (PRO2743)
P01023 1 1 2 1 5 4 Signal confident 0 α-2-macroglobulin precursor (α-2-M)
P02760111033Signal confident0AMBP protein precursor [contains α-1-microglobulin (protein HC) (complex-forming glycoprotein heterogeneous in charge) (α-1 microglycoprotein); inter-α-trypsin inhibitor light chain (ITI-LC) (bikunin) (HI-30)]
P01019 1 1 1 1 4 4 Signal 0 Angiotensinogen precursor [contains angiotensin I (Ang I); angiotensin II (Ang II); angiotensin III (Ang III) (Des-Asp[1]-angiotensin II)]
P01008 1 1 1 1 4 4 Signal 0 Antithrombin-III precursor (ATIII) (PRO0309)
P02647 1 1 2 2 6 4 Signal confident 0 Apolipoprotein A-I precursor (Apo-AI)
P02652 1 1 1 1 4 4 Signal confident 0 Apolipoprotein A-II precursor (Apo-AII) (apoa-II)
P06727 1 1 1 2 5 4 Signal confident 0 Apolipoprotein A-IV precursor (Apo-AIV)
P04114112043Signal confident0Apolipoprotein B-100 precursor (Apo B-100) [contains: apolipoprotein B-48 (Apo B-48)]
P02655 1 1 1 1 4 4 Signal confident 0 Apolipoprotein C-II precursor (Apo-CII)
P02656 1 1 1 1 4 4 Signal confident 0 Apolipoprotein C-III precursor (Apo-CIII)
P05090 1 1 1 1 4 4 Signal confident 0 Apolipoprotein D precursor (Apo-D) (apod)
P02649 1 3 2 1 7 4 Signal confident 0 Apolipoprotein E precursor (Apo-E)
Q13790 1 1 1 1 4 4 Signal confident 0 Apolipoprotein F precursor (Apo-F)
O14791 1 1 1 1 4 4 Signal 0 Apolipoprotein L1 precursor (apolipoprotein L-I) (apolipoprotein L) (apol-I) (Apo-L) (apol)
P08519101022Signal0Apolipoprotein(a) precursor (EC 3.4.21.−) (Apo(a)) (Lp(a))
P06576011022Possible signal0ATP synthase β chain, mitochondrial precursor (EC
P01160101022Signal confident0Atrial natriuretic factor precursor (ANF) (atrial natriuretic peptide) (ANP) (prepronatriodilatin) [contains: cardiodilatin-related peptide (CDP)]
P02749 1 1 1 1 4 4 Signal confident 0 β-2-glycoprotein I precursor (apolipoprotein H) (Apo-H) (B2GPI) (β(2)GPI) (activated protein C-binding protein) (APC inhibitor)
P01884100122Signal confident0β-2-microglobulin precursor
I39467001122No0Bullous pemphigoid antigen, human (fragment)
P04003111033Signal0C4b-binding protein α chain precursor (c4bp) (proline-rich protein) (PRP)
P20851110022Signal confident0C4b-binding protein β chain precursor
P05109110022No0Calgranulin A (Migration inhibitory factor-related protein 8) (MRP-8) (cystic fibrosis antigen) (CFAG) (P8) (leukocyte L1 complex light chain) (S100 calcium-binding protein A8) (calprotectin L1L subunit)
NP_001729011022No0Carbonic anhydrase I; carbonic dehydratase (Homo sapiens)
P22792111033No0Carboxypeptidase N 83-kDa chain (carboxypeptidase N regulatory subunit) (fragment)
P15169110022Signal0Carboxypeptidase N catalytic chain precursor (EC (arginine carboxypeptidase) (kinase 1) (serum carboxypeptidase N) (SCPN) (anaphylatoxin inactivator) (plasma carboxypeptidase B)
P07339110022Signal confident0Cathepsin D precursor (EC
P07711110022Signal confident0Cathepsin L precursor (EC (major excreted protein) (MEP)
P25774010122Signal confident0Cathepsin S precursor (EC
NP_005185001122No0CCAAT/enhancer binding protein β, interleukin 6-dependent
O43866110022Signal confident0CD5 antigen-like precursor (SP-α) (CT-2) (igm-associated peptide)
NP_005187002132No0Centromere protein F (350/400kd, mitosin); mitosin; centromere
P00450 1 1 1 1 4 4 Signal confident 0 Ceruloplasmin precursor (EC (ferroxidase)
NP_006421001122No0Chaperonin containing TCP1, subunit 4 (δ); chaperonin
NP_004061001122No10Chloride channel Ka; chloride channel, kidney, A; hclc-Ka (Homo sapiens)
P06276110022Signal confident1Cholinesterase precursor (EC (acylcholine acylhydrolase) (choline esterase II) (butyrylcholine esterase) (pseudocholinesterase)
P10909 1 1 1 1 4 4 Signal confident 0 Clusterin precursor (complement-associated protein SP-40,40) (complement cytolysis inhibitor) (CLI) (NA1 and NA2) (apolipoprotein J) (Apo-J) (TRPM-2)
P00740110133Signal0Coagulation factor IX precursor (EC (Christmas factor)
P12259101133Signal confident0Coagulation factor V precursor (activated protein C cofactor)
P00451101022Signal0Coagulation factor VIII precursor (procoagulant component) (antihemophilic factor) (AHF)
P00742110022Signal confident0Coagulation factor X precursor (EC (Stuart factor)
P00748 1 1 1 1 4 4 Signal confident 0 Coagulation factor XII precursor (EC (Hageman factor) (HAF)
P00488110133No0Coagulation factor XIII A chain precursor (EC (protein-glutamine γ-glutamyltransferase A chain) (transglutaminase A chain)
P05160111033Signal confident0Coagulation factor XIII B chain precursor (protein-glutamine γ-glutamyltransferase B chain) (transglutaminase B chain) (fibrin stabilizing factor B subunit)
P02462101133Signal0Collagen α 1(IV) chain precursor
P00736 1 1 1 1 4 4 Signal confident 0 Complement C1r component precursor
P09871 1 1 1 1 4 4 Signal confident 0 Complement C1s component precursor (EC (C1 esterase)
P06681111033Signal confident0Complement C2 precursor (EC (C3/C5 convertase)
P01024 1 1 1 1 4 4 Signal confident 0 Complement C3 precursor (contains C3a anaphylatoxin)
P01028 1 1 2 1 5 4 Signal 0 Complement C4 precursor (contains C4A anaphylatoxin)
P01031111033Signal confident0Complement C5 precursor (contains C5a anaphylatoxin)
P13671 1 1 1 1 4 4 Signal 0 Complement component C6 precursor
P10643111033Signal confident0Complement component C7 precursor
P07357 1 1 1 1 4 4 Signal confident 0 Complement component C8 α chain precursor
P07358111033Signal confident0Complement component C8 β chain precursor
P07360111033Signal confident0Complement component C8 γ chain precursor
P02748 1 1 1 1 4 4 Signal confident 0 Complement component C9 precursor
P00751 1 1 1 1 4 4 Signal 0 Complement factor B precursor (EC (C3/C5 convertase) (properdin factor B) (glycine-rich β glycoprotein) (GBG) (PBF2)
P08603112043Signal confident0Complement factor H precursor (H factor 1)
A40455011022No0Complement factor H-related protein (clone H 36–1) precursor, human (fragment)
P05156131053Signal0Complement factor I precursor (EC (C3B/C4B inactivator)
P48740110022Signal confident0Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.−) (Ra-reactive factor serine protease p100) (rarf) (mannan-binding lectin serine protease 1) (mannose-binding protein associated serine protease) (MASP-1)
Q04656011022No7Copper-transporting ATPase 1 (EC (copper pump 1) (Menkes disease-associated protein)
P08185111033Signal0Corticosteroid-binding globulin precursor (CBG) (transcortin)
P02741110022Signal confident0C-reactive protein precursor
P06732110022No0Creatine kinase, M chain (EC (M-CK)
P49902101022No0Cytosolic purine 5`-nucleotidase (EC
1DSN012032No0D60S N-terminal lobe human lactoferrin
P09172110022Signal confident0Dopamine β-monooxygenase precursor (EC (dopamine β-hydroxylase) (DBH)
JC2521001122Possible signal1Endothelin converting enzyme (EC 3.4.24.−) 1, umbilical vein endothelial cell form, human
NP_004416011133Signal confident0Extracellular matrix protein 1 isoform 1 precursor; secretory
P02671101133Signal confident0Fibrinogen α/α-E chain precursor (contains fibrinopeptide A)
P02675110133Signal0Fibrinogen β chain precursor (contains fibrinopeptide B)
P02751 1 1 3 1 6 4 Signal confident 0 Fibronectin precursor (FN) (cold-insoluble globulin) (CIG)
P23142110133Signal confident0Fibulin-1 precursor
O75636110022Signal confident0Ficolin 3 precursor (collagen/fibrinogen domain-containing protein 3) (collagen/fibrinogen domain-containing lectin 3 P35) (Hakata antigen)
P01225110022Signal0Follitropin β chain precursor (follicle-stimulating hormone β subunit) (FSH-β) (FSH-B)
P09104110022No0Gamma enolase (EC (2-phospho-d-glycerate hydrolyase) (neural enolase) (NSE) (enolase 2)
P06396 1 1 1 1 4 4 Signal confident 0 Gelsolin precursor, plasma (actin-depolymerizing factor) (ADF) (Brevin) (AGEL)
P14136110022No0Glial fibrillary acidic protein, astrocyte (GFAP)
Q04609111033Possible signal1Glutamate carboxypeptidase II (EC
A47531011022Possible signal1Glutamyl aminopeptidase (EC, human
NP_001494011022Signal0Glycosylphosphatidylinositol specific phospholipase D1 isoform 1
AAB34872005272No0GP120, IHRP=ITI heavy chain-related protein (internal fragment)
JW0057011022No0Gravin, human
P00737 3 3 3 1 10 4 Signal confident 0 Haptoglobin-1 precursor
P01922100122No0Hemoglobin α chain
P02023 1 1 1 1 4 4 No 0 Hemoglobin β chain
P02790111033Signal confident0Hemopexin precursor (β-1B-glycoprotein)
P05546 1 1 1 1 4 4 Signal confident 0 Heparin cofactor II precursor (HC-II) (protease inhibitor leuserpin 2) (HLS2)
Q04756010122Signal confident0Hepatocyte growth factor activator precursor (EC 3.4.21.−) (HGF activator) (HGFA)
Q14520101022Signal0HGF activator like protein (hyaluronan binding protein 2)
P04196 1 1 1 1 4 4 Signal confident 0 Histidine-rich glycoprotein precursor (histidine-proline rich glycoprotein) (HPRG)
P31151011022No0Human psoriasin (s100a7)
T14738001122Possible signal0Hypothetical protein dkfzp564a2416.1, human (fragment)
T08772001122No0Hypothetical protein dkfzp586m121.1, human (fragment)
T00063001122No0Hypothetical protein KIAA0437, human (fragment)
S40354 11 14 78 6 109 4 Signal 0 Immunoglobulin κ chain, human
P01591111033Possible signal0Immunoglobulin J chain
P08476101022Signal confident0Inhibin β A chain precursor (activin β-A chain) (erythroid differentiation protein) (EDF)
P17936100122Signal confident0Insulin-like growth factor binding protein 3 precursor (IGFBP-3) (IBP-3) (IGF-binding protein 3)
P24593101133Signal confident0Insulin-like growth factor binding protein 5 precursor (IGFBP-5) (IBP-5) (IGF-binding protein 5)
P35858111033Signal confident0Insulin-like growth factor binding protein complex acid labile chain precursor (ALS)
P01343100122Signal0Insulin-like growth factor IA precursor (IGF-IA) (somatomedin C)
P19827 1 1 2 1 5 4 Signal confident 1 Inter-α-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-α-inhibitor heavy chain 1) (Inter-α-trypsin inhibitor complex component III) (serum-derived hyaluronan-associated protein) (SHAP)
P19823 1 1 1 1 4 4 Signal confident 0 Inter-α-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (inter-α-inhibitor heavy chain 2) (inter-α-trypsin inhibitor complex component II) (serum-derived hyaluronan-associated protein) (SHAP)
Q06033 1 1 1 1 4 4 Signal 0 Inter-α-trypsin inhibitor heavy chain H3 precursor (ITI heavy chain H3) (Inter-α-inhibitor heavy chain 3) (serum-derived hyaluronan-associated protein) (SHAP)
Q14624 1 2 1 1 5 4 Signal 0 Inter-α-trypsin inhibitor heavy chain H4 precursor
A33481101022No0Interferon-induced viral resistance protein mxa, human
P29459101022Signal confident0Interleukin-12 α chain precursor (IL-12A) (cytotoxic lymphocyte maturation factor 35-kDa subunit) (CLMF p35) (NK cell stimulatory factor chain 1) (NKSF1)
P40933100122Signal0Interleukin-15 precursor (IL-15)
P05231110022Signal confident0Interleukin-6 precursor (IL-6) (B-cell stimulatory factor 2) (BSF-2) (interferon β-2) (hybridoma growth factor)
PC1102002132No0Keratin 10, type I, cytoskeletal (clone HK51), human (fragment)
NP_008985011022No0Kinesin family member 3A; kinesin family protein 3A (Homo sapiens)
P01042 1 1 4 2 8 4 Signal confident 0 Kininogen precursor (α-2-thiol proteinase inhibitor) (contains bradykinin)
P02750111033Signal0Leucine-rich α-2-glycoprotein precursor (LRG)
P18428110022Signal confident0Lipopolysaccharide-binding protein precursor (LBP)
P07195110022No0l-lactate dehydrogenase B chain (EC (LDH-B) (LDH heart subunit) (LDH-H)
P51884011022Signal confident0Lumican precursor (keratan sulfate proteoglycan lumican) (KSPG lumican)
NP_005920101022Signal confident1Melanoma-associated antigen p97 isoform 1, precursor
P10636101022No0Microtubule-associated protein τ (neurofibrillary tangle protein) (Paired helical filament-τ) (PHF-τ)
I37550001122No0Mismatch repair protein MSH2, human
Q02241001122No0Mitotic kinesin-like protein-1 (kinesin-like protein 5)
P08571110022Signal confident0Monocyte differentiation antigen CD14 precursor (myeloid cell-specific leucine-rich glycoprotein)
P35579011133No0Myosin heavy chain, nonmuscle type A (cellular myosin heavy chain, type A) (nonmuscle myosin heavy chain-A) (NMMHC-A)
P12882010122No0Myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d)
NP_006380011022Signal confident1Oxygen regulated protein precursor; oxygen regulated protein
P01270110022Signal0Parathyroid hormone precursor (Parathyrin) (PTH) (Parathormone)
NP_006784001122Possible signal0Peroxiredoxin 3; antioxidant protein 1; thioredoxin-dependent
Q15648100122No0Peroxisome proliferator-activated receptor binding protein (PBP) (PPAR binding protein) (thyroid hormone receptor-associated protein complex component TRAP220) (thyroid receptor interacting protein 2) (TRIP2) (p53 regulatory protein RB18A)
P04180110022Signal confident2Phosphatidylcholine-sterol acyltransferase precursor (EC (lecithin-cholesterol acyltransferase) (phospholipid-cholesterol acyltransferase)
NP_001074011022No0Phosphodiesterase 5A isoform 1; cgmp-binding cgmp-specific
P15259111033No0Phosphoglycerate mutase 2 (EC (EC (EC (phosphoglycerate mutase isozyme M) (PGAM-M) (BPG-dependent PGAM 2) (muscle-specific phosphoglycerate mutase)
NP_006209001122No0Phosphoinositide-3-kinase, catalytic, α polypeptide
P36955011133Signal confident0Pigment epithelium-derived factor precursor (PEDF) (EPC-1)
P03952111033Signal0Plasma kallikrein precursor (EC (plasma prekallikrein) (kininogenin) (Fletcher factor)
P05155111033Signal confident0Plasma protease C1 inhibitor precursor (C1 Inh) (C1Inh)
P02753111033Signal confident0Plasma retinol-binding protein precursor (PRBP) (RBP) (PRO2222)
P05154111033Signal confident0Plasma serine protease inhibitor precursor (PCI) (protein C inhibitor) (plasminogen activator inhibitor-3) (PAI3) (acrosomal serine protease inhibitor)
P05121110022Signal confident0Plasminogen activator inhibitor-1 precursor (PAI-1) (endothelial plasminogen activator inhibitor) (PAI)
P00747 1 1 2 1 5 4 Signal 0 Plasminogen precursor (EC (contains angiostatin)
P02775100122Signal0Platelet basic protein precursor (PBP) (small inducible cytokine B7) (CXCL7)
P02776100122Signal confident0Platelet factor 4 precursor (PF-4) (CXCL4) (oncostatin A) (Iroplact)
P43034110022No0Platelet-activating factor acetylhydrolase IB α subunit (EC (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45-kDa subunit) (PAF-AH α) (PAFAH α) (Lissencephaly-1 protein) (LIS-1)
NP_006197001122Signal confident1Platelet-derived growth factor receptor α precursor (Homo sapiens)
NP_000436001122No0Plectin 1, intermediate filament binding protein 500 kDa; plectin 1
P20742111033Signal confident0Pregnancy zone protein precursor
P07288201032Signal confident0Prostate-specific antigen precursor (EC (PSA) (γ-seminoprotein) (kallikrein 3) (semenogelase) (seminin) (P-30 antigen)
P07237110022Signal confident0Protein disulfide isomerase precursor (PDI) (EC (prolyl 4-hydroxylase β subunit) (cellular thyroid hormone binding protein) (P55)
NP_002725011022No0Protein kinase, camp-dependent, regulatory, type I, α
AAB22439001122No0Protein tyrosine phosphatase; ptpase (Homo sapiens)
P00734 1 1 2 1 5 4 Signal 0 Prothrombin precursor (EC (coagulation factor II)
P22614200132Signal confident0Putative serum amyloid A-3 protein
P04626101022Signal confident2Receptor protein-tyrosine kinase erbb-2 precursor (EC (p185erbb2) (NEU proto-oncogene) (C-erbb-2) (tyrosine kinase-type cell surface receptor HER2) (MLN 19)
NP_005397001122No0Rho-associated, coiled-coil containing protein kinase 1; p160rock
P49908101022Signal confident0Selenoprotein P precursor (sep)
NP_006206011022Signal confident0Serine (or cysteine) proteinase inhibitor, clade A (α-1)
P02787 1 1 1 1 4 4 Signal confident 0 Serotransferrin precursor (transferrin) (siderophilin) (β-1-metal binding globulin) (PRO1400)
P02768111033Signal confident0Serum albumin precursor
P02735 1 1 1 1 4 4 Signal confident 0 Serum amyloid A protein precursor (SAA) (contains amyloid protein A (amyloid fibril protein AA)
P35542111033Signal0Serum amyloid A-4 protein precursor (constitutively expressed serum amyloid A protein) (C-SAA)
P02743110022Signal confident0Serum amyloid P-component precursor (SAP) (9.5S α-1-glycoprotein)
P27169111033Signal0Serum paraoxonase/arylesterase 1 (EC (EC (PON 1) (serum aryldiakylphosphatase 1) (A-esterase 1) (aromatic esterase 1) (K-45)
P04278110022Signal0Sex hormone-binding globulin precursor (SHBG) (sex steroid-binding protein) (SBP) (testis-specific androgen-binding protein) (ABP)
P08240010122Possible signal0Signal recognition particle receptor α subunit (SR-α) (docking protein α) (DP-α)
AAC83183001122No0Similar to human hsgcn1 U77700 (PID:g2282576); similar to yeast
P09486110022Signal confident0SPARC precursor (secreted protein acidic and rich in cysteine) (osteonectin) (ON) (basement membrane protein BM-40)
P29508201032No0Squamous cell carcinoma antigen 1 (SCCA-1) (protein T4-A)
NP_003060011022No0SWI/SNF-related matrix-associated actin-dependent regulator of
P05452110022Signal confident0Tetranectin precursor (TN) (plasminogen-kringle 4 binding protein)
P07996110133Signal confident0Thrombospondin 1 precursor
P01266101022Signal confident0Thyroglobulin precursor
P05543110022Signal confident0Thyroxine-binding globulin precursor (T4-binding globulin)
P02766 1 1 1 1 4 4 Signal confident 0 Transthyretin precursor (prealbumin) (TBPA) (TTR) (ATTR)
P07477101022Signal confident0Trypsin I precursor (EC (cationic trypsinogen)
P19320101022Signal confident1Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100)
P18206010122No0Vinculin (metavinculin)
P02774 1 1 2 1 5 4 Signal confident 0 Vitamin D-binding protein precursor (DBP) (group-specific component) (GC-globulin) (VDB)
P07225111033Signal confident0Vitamin K-dependent protein S precursor
P04070110022Signal confident0Vitamin-K dependent protein C precursor (EC (autoprothrombin IIA) (anticoagulant protein C) (blood coagulation factor XIV)
P04004 1 1 1 1 4 4 Signal confident 0 Vitronectin precursor (serum spreading factor) (S-protein) (V75) (contains vitronectin V65 subunit; vitronectin V10 subunit; somatomedin B)
NP_000213100122Signal confident2V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
P04275110133Signal confident0Von Willebrand factor precursor (vwf)
P25311111033Signal confident0Zinc-α-2-glycoprotein precursor (Zn-α-2-glycoprotein) (Zn-α-2-GP)