Table IV

Prospective ovarian cancer screening studies in women with family history of ovarian or breast cancer or personal history of breast cancer

StudyPopulationaScreening protocolNo. screened (premenopausal %)No. referred for diagnostic tests (%)baNo. of invasive EOC detected (borderline tumors)cCancers in screen-negative women
Bourne et al. 1994 (79)Aged >17 (mean 47); F/H of Ov cancerTVS then CDI1,602 (60%)62 (3.8)4(3) 2 stage I2 PP (2–8 months) 4 EOC (24-44 months)
Weiner et al. 1993 (80)P/H Br cancerTVS and CDI60012 (3)31 stage INot stated
Muto et al. 1993 (81)Aged >25; F/H of Ov cancerTVS and CA125384 (85.4)15 (3.9)0Not stated
Schwartz et al. 1995 (82)Aged >30; F/H of Ov cancerTVS and CDI and CA1252471 (0.4)0Not stated
Belinson et al. 1995 (83)Aged >23 (mean 43); F/H of Ov cancerTVS and CDI and CA1251372 (1.5)1Not stated
Menkiszak et al. 1998 (84)Aged >20; F/H of Br/Ov cancerTVS and CA125 (6 monthly)124Not available1 (3)Not available
Karlan et al. 1993 (85)Aged >35; F/H of Ov, Br, Endo, colon cancer; P/H Br cancerTVS and CDI and CA125 (6 monthly till 1995 then annually)597d (75)10 (1.7)0 (1)Not stated
Karlan et al. 1999 (86)Aged >35; F/H of Ov, Br, Endo, colon cancer; P/H Br cancerTVS and CDI and CA125 (6 monthly till 1995 then annually)1,261Not stated1 EOC, 3 PP (2) 1 stage I4 PP (5, 6, 15, 16 months)
Dorum et al.1996 (87)Aged >25 (mean 43); strict criteria for F/H of Br/Ov cancerTVS and CA125180d16 (8.9)4 (3)d2e
Dorum et al. 1999 (88)Aged >25 (mean 43); strict criteria for F/H of Br/Ov cancerTVS and CA125803Not stated16 (4)Not stated
Scheuer et al. 2002 (89)Aged >35; BRCA1 /2 mutation carriersTVS and CA125 (6 monthly)6222 (35.5) 10 had surgery54 EOC, 1 PP3 stage I0f
  • a P/H, personal history; F/H, family history; Ov, ovarian; Br, breast; Endo, endometrial.

  • b Following positive secondary screens.

  • c EOC, epithelial ovarian cancer; PP, primary peritoneal cancer.

  • d Not included in total as there are more recent updates on the trial.

  • e A further 13 women underwent oophorectomy for breast cancer; two had ovarian cancer not detected by TVS.

  • f Two women who opted for oopherectomy with normal scans and CA125 had stage 1 ovarian cancer.