Table I

Dimerization of the HER-2/neu receptor and signaling pathway

Dimerization partnerHER-1 (EGFR)HER-2HER-3HER-4
LigandsTGF-?NoneNRG1NRG1
EGFHeregulinNRG2
HB-EGFHeregulin
Epiregulin
Amphiregulin
?-cellulin
HER-1SRCP13K: CytoskeletonNoneNone
PI3KAKT: Anti-apoptosis
AKT
HER-2NoneRAS: TranscriptionRAS: TranscriptionNone
RAS: Cell cycle progressionRAS: Cell cycle progression
P13KP13K
HER-3NoneP13K: CytoskeletonNoneNone
AKT: Anti-apoptosis
None
HER-4NoneNoneNone