Table V

Mechanism of action of trastuzumab a

Antibody-dependent cellular cytotoxicity
    Stimulation of natural killer cells
Immune system mediated
Prevention of HER-2/neu receptor dimerization
Downstream signaling is reduced or completely interrupted
Direct cell cycle inhibitor
    Induces p27kip1 cyclin-dependent kinase inhibitor to slow G1 phase
Anti-angiogenesis
    Reduces angiogenic factors: VEGF, TGF-α and PAI-1
Pro-apoptotic
    Inhibits Akt signaling
  • a Modified from Nahata, R., and Esteva, F. J. (2003) HER-2 targeted therapy: Lessons learned and future directions. Clin. Cancer Res. 9, 5078–5084.