Table I

Signaling proteins known to be involved in CSF-1 receptor signaling that bind to a phosphopeptide based on the Tyr-973 autophosphorylation site

Signaling proteinInteraction with the CSF-1 receptorReferences
c-CblBinds in vivo and in vitro to Tyr-973 and is tyrosine-phosphorylated in response to CSF-115 , 42–44 , 69
Grb2Binds in vivo and in vitro to Tyr-69742 , 46 , 58 , 70–73
SHIPTyrosine-phosphorylated in response to CSF-1, can associate with the receptor, a binding site has not been identified32 , 46 , 47 , 53
Shp1Tyrosine-phosphorylated in response to CSF-1, a binding site on the receptor has not been identified49 , 52
Shp2Tyrosine-phosphorylated in response to CSF-1, associates with the receptor in some cells, a binding site has not been identified53 , 74 , 75
SosAssociates with the CSF-1 receptor through Grb242 , 46 , 72