Table I

Proteins sharing significant changes between PMA versus control conditions as filtered by RSC significance

Gene symbolSpectral countsPeak area intensitymRNA
RSC(1,2)aRSC(2,3)bSC1cSC2cSC3cp(1,2)d,sp(2,3)e,sRPA(1,2)fRPA(2,3)gCPhCPiS.E.jS.E.kp(1,2)lp(2,3)mRmRNA(1,2)nRmRNA(2,3)op(1,2)p,sp(2,3)q,sIPI annotationr
SPTAN13.32−2.4901111.20E-041.93E-03001.35−0.994.21E-074.91E-06IPI00015786.2
FLNA2.60−0.37218141.28E-044.40E-01−0.19060.430.681.53−0.814.30E-053.53E-03IPI00333541.3
MYH9 2.14−0.8731791.00E-031.03E-01−1.57020.421.53−1.091.07E-041.46E-03IPI00019502.1
FLNB 2.92−0.390861.15E-035.68E-01000.19−0.201.61E-013.56E-01IPI00289334.1
SPTBN1 1.80−2.0652041.80E-035.78E-04−0.71010.43−0.429.27E-033.81E-02IPI00328230.1
BCLAF1 2.56−2.570605.29E-035.17E-0300−0.17−0.251.71E-014.57E-02IPI00006079.1
ASNS −2.520.816015.85E-033.41E-0100−1.931.354.06E-053.74E-04IPI00215927.1
P4HB 2.22−1.001947.50E-031.55E-01−1.061.34110.47−0.584.22E-022.39E-02IPI00010796.1
SND1 1.78−0.6631389.55E-032.54E-010.12−0.79250.230.790.380.21−0.321.01E-011.60E-01IPI00140420.2
SARS −1.730.7413361.14E-023.43E-01−1.671.2911−0.800.434.28E-056.93E-03IPI00220637.1
PTPN1 2.35−2.360501.15E-021.13E-02000.29−0.366.80E-037.98E-03IPI00297261.3
ELAVL1 2.35−1.510511.15E-029.55E-021.0501−0.440.362.58E-021.06E-02IPI00301936.3
ANXA5 2.35−2.360501.15E-021.13E-02002.00−1.401.43E-052.50E-04IPI00329801.6
DUT −2.30501.25E-020−1.304.23E-05IPI00013679.1
HMGN3 −2.300.815011.25E-023.41E-0100−0.490.281.97E-021.59E-01IPI00018842.2
HSPA5 1.57−1.8941431.51E-025.26E-03−1.00200.640.47−0.812.92E-031.31E-04IPI00003362.1
VIM 1.57−0.9341471.51E-021.14E-01−0.81−3.04240.170.960.051.99−1.495.87E-071.31E-06IPI00418471.1
PP −2.021.668161.63E-025.80E-02−1.390.0011−0.610.331.20E-034.75E-02IPI00015018.1
FLNC 1.67−2.0731221.64E-024.92E-03−1.43011.04−0.522.19E-039.74E-02IPI00178352.3
RCD-8 2.10−1.260412.55E-021.77E-01000.15−0.337.07E-013.43E-01IPI00376317.3
RUVBL1 −2.051.734032.73E-026.12E-0200−0.420.237.29E-048.32E-02IPI00021187.1
TPR −2.051.354022.73E-021.40E-0100−0.180.081.56E-024.06E-02IPI00022970.2
MCM2 −2.051.354022.73E-021.40E-0100−1.390.911.40E-043.21E-03IPI00184330.3
STMN1 −2.052.294052.73E-021.28E-0200−1.100.817.12E-067.18E-05IPI00240029.6
H2AFY 1.90−0.441752.74E-025.43E-010.11−1.07120.050.090.031.74E-013.56E-01IPI00059366.1
HMBS −1.851.197143.05E-021.94E-0100−2.021.323.24E-068.31E-05IPI00028160.1
HNRPU 1.71−0.811635.19E-023.08E-01−0.3501−0.670.225.30E-032.43E-01IPI00025054.1
TRA1 1.01−1.1791985.21E-022.81E-021.38−1.77440.780.470.180.030.67−0.955.68E-041.63E-03IPI00027230.1
VCL 1.54−0.202875.21E-027.64E-011.97−0.46240.080.750.580.73−0.093.54E-048.33E-01IPI00291175.3
VASP 1.54−0.852845.21E-022.36E-01000.54−0.521.32E-031.08E-02IPI00301058.2
UAP1 −1.67−0.036115.68E-029.88E-0100−0.35−0.261.68E-014.24E-01IPI00000684.3
DDX21 −1.671.666165.68E-025.80E-02−0.0310−0.770.117.35E-043.98E-01IPI00015953.2
MCM6 −1.67−0.036115.68E-029.88E-0100−0.450.301.64E-021.43E-01IPI00031517.1
PAI-RBP1 −1.200.6211477.42E-023.94E-01−0.050.02310.200.82−0.500.175.48E-031.09E-01IPI00412714.1
IQGAP1 1.11−0.7251278.28E-022.33E-01−0.01−2.12210.460.59−0.491.12E-028.08E-02IPI00009342.1
ATIC −1.251.5093118.71E-023.35E-021.00−0.03230.441.060.98−0.820.683.09E-031.43E-02IPI00289499.1
FUS 1.37−1.382729.02E-028.82E-0200−0.28−0.252.48E-012.30E-01IPI00221354.1
LMNA 1.50−0.031559.72E-029.70E-01−1.17020.040.510.045.28E-024.30E-01IPI00021405.1
GANAB 1.50−0.981529.72E-022.52E-010.81100.040.058.41E-019.17E-01IPI00383581.1
SNRPD1 −1.32−0.577219.94E-025.76E-0100−0.780.354.89E-031.61E-01IPI00302850.3
MYH10 −1.320.667249.94E-024.45E-011.1010−0.590.323.58E-037.03E-02IPI00397526.1
  • a RSC calculated as in Equation 1 with f = 1.25, comparing PMA/control ratio.

  • b RSC comparing PMA + U0126/PMA ratio.

  • c Spectral counts for the following conditions: 1) control, 2) PMA, and 3) PMA + U0126.

  • d p values for RSC (PMA/control).

  • e p values for RSC (PMA + U0126/PMA).

  • f RPA comparing PMA/control ratio.

  • g RPA comparing PMA + U0126/PMA ratio.

  • h Number of peptides in common between control and PMA.

  • i Number of peptides in common between PMA and PMA + U0126.

  • j S.E. for RPA (PMA/control).

  • k S.E. for RPA (PMA + U0126/PMA).

  • l p values for RPA (PMA/control).

  • m p values for RPA (PMA + U0126/PMA).

  • n RmRNA comparing PMA/control ratio.

  • o RmRNA comparing PMA + U0126/PMA ratio.

  • p p values for RmRNA (PMA/control).

  • q p values for RmRNA(PMA + U0126/PMA).

  • r International Protein Index (IPI) version 3.0, released November 2004.

  • s Scientific notation, base 10.