Table I

Proteins identified by MS/MS that vary in abundance within individuals over a 2-week time period

Column 2 is the GenBank™ accession number. “Number” indicates the number of individuals that share a greater than 1.5-fold change. Column 4 is the -fold change in protein abundance comparing time 2 with time 1. Direction of the change was ignored, and only the absolute value of the -fold change was used for calculation. Average ± S.D. were given for changes that are shared among several individuals as well as for proteins for which several isoforms have been identified in the same individual. “p value” indicates the statistical significance of a protein differing in abundance between the two time points in one or more individuals.

ProteinGenBank™ IDNumber-Fold changep value
Transthyretin 339685 61.92 ± 0.467.53 × 10−12
Chromogranin A 180529 31.79 ± 0.095.32 × 10−5
Complement component C4A 443671 31.73 ± 0.315.32 × 10−5
Hemopexin precursor 386789 31.63 ± 0.095.32 × 10−5
Osteopontin-a 992948 31.50 ± 0.115.32 × 10−5
β fibrinogen precursor 182430 23.33 ± 1.210.00283
Apolipoprotein E 178849 23.13 ± 0.030.00283
Complement component 3 precursor 4557385 22.81 ± 1.600.00283
Semaphorin L 3551779 22.06 ± 0.740.00283
Aprotinin 58005 22.05 ± 0.510.00283
Prostaglandin D2 synthase 54696706 21.97 ± 0.170.00283
α2-Macroglobulin 177872 21.75 ± 0.180.00283
Fibulin 1 precursor 106018 21.64 ± 0.310.00283
Chromogranin B precursor 4502807 21.64 ± 0.120.00283
Ubiquitin 13569612 21.60 ± 0.060.00283
Fibrinogen γ 71828 1a3.87 ± 2.550.0811
Apolipoprotein H precursor 4557327 1a2.55 ± 0.300.0811
PRO 1400 6650772 1a1.99 ± 0.580.0811
Transferrin 31415705 1a1.66 ± 0.180.0811
Pyruvate kinase 2117873 16.020.0811
Complement C8-β propeptide 29575 15.490.0811
Angiotensinogen 532198 14.720.0811
Coagulation factor XII 180359 12.150.0811
Scrapie-responsive protein 1 37183198 11.620.0811
Cerebroside sulfate activator protein 337760 11.600.0811
α albumin 4501987 11.520.0811
  • a Several isoforms were identified in the same individual.