Table II

CSF proteins (identified by MS/MS) found to be differentially expressed between CDR 0.5 and CDR 0 groups

Column 1 is the protein spot ID from 2-D DIGE. For spots 1 and 5, two proteins were identified. Column 2 is the protein ID. The protein that had the higher matching score (when MS/MS results were used to search the protein databases) is listed first. Column 3 is the GenBank™ accession number. Column 4 is the statistical significance (p value) of a group-associated difference in a given protein. Column 5 is the direction of change (increase vs. decrease) when using the CDR 0 group as baseline.

Spot IDProteinGenBank™ IDp valueDirection of change
1α1β-Glycoprotein 69990 0.011Decrease
Complement component 3 precursor 4557385 0.011Decrease
2Apolipoprotein H precursor 4557327 0.0071Decrease
3Chitinase 3-like 1 4557018 0.011Increase
4Chitinase 3-like 1 4557018 0.014Increase
5Prostaglandin D2 synthase 55962672 0.015Increase
Chitinase 3-like 1 4557018 0.015Increase
6Prostaglandin D2 synthase 54696706 0.00022Increase
7Prostaglandin D2 synthase 54696706 0.016Increase
8Prostaglandin D2 synthase 54696706 0.011Increase
9Cystatin C 181387 0.019Increase
10Thioredoxin 231098 0.0058Increase
11β2-Microglobulin 34616 0.0022Increase