Table II

Common proteins from lysosomes, phagosomes, and melanosomes

Common proteins from lysosomes, phagosomes, and melanosomes were found by comparing lists of proteins from published proteomic studies. MHC, major histocompatibility complex; MDR, multidrug resistance; TAP, transporter associated with antigen processing; SNAP, soluble N-ethylmaleimide-sensitive factor attachment protein.

Protein NameLysosome GI numberPhagosome GI numberMelanosome GI number
Metabolism
    CYP4A328461155296449
    Glyceraldehyde-3-phosphate dehydrogenase8393418P16858
    Peroxiredoxin 116923958P35700
Immunity
    Macrophage expressed gene 112018298I52603
    MHC class I α chain940825CAA06194
Biosynthesis
    Eukaryotic translation elongation factor 1 α215805031P10126
    Heat shock 70-kDa protein 5, GRP78, BiP25742763P20029p11021
    Protein disulfide isomerase (ER60)91897P27773P30101
    Ribophorin I6981486P04843
Membrane receptors/signaling and cell adhesion
    Phosphatidylinositol 4-kinase type II1675855413559514
    Similar to ras-related C3 botulinum toxin substrate 1 isoform Rac1b34870449P15154
Molecular transport
    ATP-binding cassette, sub-family B (MDR/TAP), member 61803478511245444
    Niemann-Pick C16679104O15118
    V-ATPase Subunit B17105370P50517P21281
    V-ATPase Subunit D3955100P12953
    V-ATPase Subunit E13097342P50518P36543
    Voltage-dependent anion channel 16755963Q60932P21796
Membrane structure and lipid rafts
    CD36 antigen-like 2 (LIMPII)16758914P27615
    Flotillin-113124118O089173599573
    Flotillin-213124119Q14254
    LAMP-16981144P11438P11279
    LAMP-28393690P17046
    Prohibitin6679299P24142
    Stomatin (erythrocyte band 7 integral membrane protein 7.2b)7710018P54116P27105
Hydrolases/cofactors
    β-Glucuronidase893510P12265
    Cathepsin L67650P06797
    Cathepsin Z34978341CAB44494
    Nicastrin27819651Q92542
    Prosaposin94388051360694
    Protective protein for β-galactosidase6679437P16675
Secreted
    Ferritin light chain, rat2119695P29391
    Peptidylprolyl isomerase C-associated protein (mama)20806135397800
Vesicular and protein trafficking
    Arl10C12838871AI006608
    heat shock protein 8; Heat shock cognate protein 70; heat shock 70-kDa protein 813242237P08109
    RAB11B, member RAS oncogene family14249144P46638
    Rab213929006P53994
    Rab5C27689505P35278
    Rab713027392P51150P51149
    SNAPα2143586P54921
    Ubiquitin706371167510P02248
Number of proteins reported and used for comparson21511768