Table I

Comparison of the use of pAbs, mAbs, recAbs, and msAbs

ParameterpAbmAbrecAbmsAb
Uniform epitope specificity+++
Renewable resource+/−+++/−
Need to use animalsYesYesNoYes
Suitability for diagnostics+++++++
Suitability for therapeuticsa++/−
Suitability for “pull-down”++/−+/−+
Suitability for protein arrays+++++++
Detection of denaturated proteins+++/−+/−++
Need for screeningNoYesYesNo
  • a pAbs have been used for many decades as vaccines (gammaglobulin).