Table II

Summary of putative cargo proteins associated with immunoisolated AQP2 vesicles (see supplementary tables for fully annotated list)

“Cargo” is defined here as proteins that are putatively carried in or attached to vesicles but are not part of the trafficking apparatus. ClC-K, kidney-specific chloride channel; CHIF, corticosteroid hormone-induced factor.

    Adenine nucleotide transporter
    Claudin 4
    ClC-K chloride channel
    FXYD-2a and -2b (Na/K-ATPase, γ subunit)
    FXYD-4 (CHIF)
    Na/K-ATPase, α1 subunit
    Na/K-ATPase, α2 subunit
    Na/K-ATPase, β1 subunit
    Na+ channel, voltage-gated (rSkM1)
    Aminopeptidase N
    Insulin-regulated aminopeptidase (IRAP)
Adhesion molecules
    Integrin α2
    Integrin α3
    Integrin α5
    Integrin β1
    Insulin-like growth factor receptor-2
    Lutheran blood group antigen (laminin receptor)
    Membrane progesterone receptor
    Scavenger receptor class B, member 2
    Apolipoprotein E
    CD59 (protectin)
    Defender against cell death
    Lysosomal membrane glycoproteins 1 and 2
    Membrane-bound C2 domain-containing protein
    Plasmalemma vesicle-associated protein
    SPFH domain family, members 1 and 2
    Transmembrane emp24 protein
    Transmembrane protein 4
    Tumor-associated calcium signal transducer 1