Table II

Summary of putative cargo proteins associated with immunoisolated AQP2 vesicles (see supplementary tables for fully annotated list)

“Cargo” is defined here as proteins that are putatively carried in or attached to vesicles but are not part of the trafficking apparatus. ClC-K, kidney-specific chloride channel; CHIF, corticosteroid hormone-induced factor.

Transporters/channels
    Adenine nucleotide transporter
    Aquaporin-1
    Aquaporin-2
    Claudin 4
    ClC-K chloride channel
    Clp55
    FXYD-2a and -2b (Na/K-ATPase, γ subunit)
    FXYD-4 (CHIF)
    Na/K-ATPase, α1 subunit
    Na/K-ATPase, α2 subunit
    Na/K-ATPase, β1 subunit
    Na+ channel, voltage-gated (rSkM1)
Enzymes
    Aminopeptidase N
    Ceruloplasmin
    Insulin-regulated aminopeptidase (IRAP)
Adhesion molecules
    Cadherin-16
    Integrin α2
    Integrin α3
    Integrin α5
    Integrin β1
Receptors
    Insulin-like growth factor receptor-2
    Lutheran blood group antigen (laminin receptor)
    Membrane progesterone receptor
    Scavenger receptor class B, member 2
Miscellaneous
    Agrin
    Apolipoprotein E
    CD59 (protectin)
    Defender against cell death
    Endomucin
    Lysosomal membrane glycoproteins 1 and 2
    Membrane-bound C2 domain-containing protein
    Plasmalemma vesicle-associated protein
    RAP1
    SPFH domain family, members 1 and 2
    Transmembrane emp24 protein
    Transmembrane protein 4
    Tumor-associated calcium signal transducer 1