Table II

Tyrosine-phosphorylated proteins not previously reported in EGFR signaling

Of the 58 proteins identified in the analysis of the first biological sample, six have not been previously associated with the EGFR signaling network. Protein identification, tyrosine phosphorylation site, and time course profile data are provided for these six proteins. *, p < 0.05; **, p < 0.01; ***, p < 0.001.

ProteinSiteRatio
0 min:5 min10 min:5 min30 min:5 min
Chromosome 20 ORF 18 (HOIL-1)pY2880.026 ± 0.034***1.950 ± 0.156**0.441 ± 0.012***
Hypothetical protein FLJ14564pY4130.66 ± 0.040.956 ± 0.0630.719 ± 0.023
Hypothetical protein FLJ30532 (MARVELD2)pY230.0000.7530.534
Retinoic acid induced 3pY3200.725 ± 0.1171.177 ± 0.0270.891 ± 0.029
KIAA0606 proteinpY20600.1400.6710.413
KIAA1217 proteinpY3930.4561.1020.952