Table II

Proteins identified in urinary exosomes that are associated with renal diseases and hypertension (5)

Diseases or syndromesIdentified proteins
Autosomal dominant and autosomal recessive nephrogenic diabetes insipidusAquaporin-2
Antenatal Bartter syndrome type 1Sodium potassium chloride cotransporter-2
Gitelman syndromeThiazide-sensitive Na-Cl cotransporter
Autosomal recessive pseudohypoaldosteronism type 1Epithelial sodium channel α, β, γ
Liddle syndromeEpithelial sodium channel β, γ
Familial renal hypomagnesemiaFXYD domain-containing ion transport regulator-2
Autosomal recessive syndrome of osteopetrosis with renal tubular acidosisCarbonic anhydrase II
Proximal renal tubular acidosisCarbonic anhydrase IV
Autosomal dominant polycystic kidney disease type 1Polycystin-1
Medullary cystic kidney disease 2 and familial juvenile hyperuricemic nephropathyTamm-Horsfall protein (uromodulin)
Autosomal recessive steroid-resistant nephrotic syndromePodocin
Fechtner syndrome and Epstein syndromeNonmuscle myosin heavy chain IIA
2,8-Dihydroxyadenine urolithiasisAdenine phosphoribosyltransferase
HypertensionAngiotensin I-converting enzyme isoform-1, aminopeptidase A, aminopeptidase N, aminopeptidase P, neprilysin, 15-hydroxyprostaglandin dehydrogenase (NAD), dimethylarginine dimethylaminohydrolase-1