Table VI

Selected inflammation-related proteins identified in this study

LPS, lipopolysaccharide; MMPs, matrix metalloproteases.

Protein nameFunction
Acute phase reactants
    α1-Acid glycoproteins 1, 2Binding protein
    α1-AntitrypsinProtease inhibitor
    α2-AntiplasminCoagulation cascade
    α2-MacroglobulinInhibitor of several serum proteases
    C-reactive proteinOpsonin
    CeruloplasminCopper transport protein
    FerritinIron transport
    FibrinogenClotting formation
    FibronectinClotting formation
    HaptoglobinScavenger
    HemopexinHeme binding
    Heparin cofactor-2Proteinase inhibitor
    KallikreinVascular permeability and dilatation
    LPS-binding proteinInnate immunity
    Manganese-superoxide dismutaseAntioxidant
    Mannose-binding protein CInnate immunity
    PlasminogenClotting, fibrinolysis
    Plasminogen activator inhibitor-1Protease inhibitor
    Serum amyloid AScavenger
    Serum amyloid PFormation of IgG immune complexes
Cytokines and growth factors
    Interleukin 2Growth factor
    Macrophage colony-stimulating factorColony stimulation
    Tumor necrosis factor receptor 1, 2Anti-inflammatory
    Interleukin 1 receptor 2Anti-inflammatory
    Interleukin 6 receptorAnti-inflammatory
    CD14Anti-inflammatory
    Interleukin 1 receptor antagonistAnti-inflammatory
    Macrophage inflammation protein 1Chemokine
    EotaxinChemokine
    Hemofiltrate CC chemokine 1Chemokine
    Transforming growth factor-βGrowth factor
    Vascular endothelial growth factorGrowth factor
    Insulin-like growth factors 1, 2Growth factor
    Platelet-derived growth factorGrowth factor
Complement proteins and coagulation factors
    C2, C3, C4, C5, C9Complement component
    Coagulation Factors V, VII–XIIICoagulation protein
    Protein CDegrades coagulation proteins
    von Willebrand factorCoagulation protein
    ThrombomodulinBinds thrombin
    Antithrombin IIICoagulation inhibitor
    Tissue factor pathway inhibitorCoagulation inhibitor
Hormones
    ReninFluid regulation
    LeptinEnergy balance
    IGF-binding proteins 1–6Carrier proteins
Extracellular matrix proteins
    Laminins 1–4Matrix protein
    Collagens I, III, IVMatrix protein
    NidogenCell-cell communication
    FibronectinMatrix protein
    Thrombospondins I, II, IVCell adhesion
    Vitronectin
    Tenascin
Cell adhesion molecules
    Intercellular adhesion molecules 1–3Cell adhesion
    Activated leukocyte adhesion moleculeCell adhesion
    Contactins 1–4Cell adhesion
    Mucosal addressin cell adhesion moleculeCell recruitment
    Neural cell adhesion moleculeCell adhesion
    Vascular cell adhesion molecule 1Cell adhesion
    Integrins α, βCell adhesion
    E-selectinCell adhesion
    L-selectinCell adhesion
    P-selectinCell adhesion
Secreted proteases and protease inhibitors
    Matrix metalloproteases 2, 9, 13, 14Collagenases, elastases, and stromelysins
    Bone morphogenetic protein 1Regulatory protein
    Metalloproteinase inhibitors 1, 2Endogenous inhibitors of collagenases and MMPs
    Cathepsins B, D, FRegulatory protease
Other proteins and immunoglobulins
    AlbuminOsmotic regulation
    TransthyretinProtein carrier
    TransferrinIron binding
    Retinol-binding proteinProtein carrier
    Immunoglobulins γ, α, μHost defense