Table II

Changes in gene expression during osteoclastogenesis detected by real time PCR

Gene-Fold changea
Cation-dependent MPR1.59 ± 0.32
Cation-independent MPR1.91 ± 0.45
TRAcP319.57 ± 57.55
Cathepsin K135.30 ± 36.25
Cathepsin D−1.31 ± 0.30
Legumain−1.84 ± 0.49
β-Glucuronidase1.60 ± 0.31
  • a Average -fold change ratio in mRNA expression in Raw 264.7 cells vs. osteoclasts (p < 0.05).