Table III

Immunohistochemical detection of markers in pure apocrine carcinomas

Data were determined by IHC analysis as described under “Experimental Procedures.” Neg, negative; Pos, positive.

Tumor markerRH-34697RH-21990RH-9777RH-10515RH-13319RH-24678
Carcinoma in situInvasive areaCarcinoma in situInvasive areaCarcinoma in situInvasive areaCarcinoma in situInvasive areaCarcinoma in situInvasive areaCarcinoma in situInvasive area
ER-α, PRNegNegNegNegNegNegNegNegNegNegNegNeg
p53NegNegNegPosNegNegWeak PosWeak PosNegNegPosPos
15-PGDHPosPosPosPosPosPosPosPosPosPosNegNega
HMG-CoA reductasePosPosPosNegNegNegNegNegNegNegNegNeg
COX-2PosPosNegNegPosNegPosPosNegNegPosPos
PsoriasinPosPosPos and NegPosNegNegPosPosPosPosPosPos
  • a Lack of expression of 15-PGDH by tumor RH-24678 was confirmed by 2D PAGE (see Fig. 15D).