Table III

Protein correlation profiling

The first group in the table represents a number of known mitochondrial proteins with 0.05 < χ2 < 0.2. The second group includes a number of high confidence proteins not previously experimentally identified in mitochondria but with 0.05 < χ2 < 0.2. Actin might perhaps be explained in terms of a tight association with the mitochondrial membrane. The last group shows the χ2 value of some contaminants of mitochondria. VDAC, voltage-dependent anion channel.

Accession no.Descriptionχ2
Known mitochondrial proteins
    P15999ATP synthase, α chain0.14
    P10719ATP synthase, β chain0.16
    P14408Fumarate hydratase0.10
    XP_215176NADH dehydrogenase (ubiquinone) flavoprotein 10.05
    XP_214977NADP+-specific isocitrate dehydrogenase0.17
    Q60587Trifunctional enzyme, β subunit0.12
    XP_217267Ubiquinol-cytochrome c reductase complex core 10.01
    P32551Ubiquinol-cytochrome c reductase complex core 20.11
    Q9Z2L0VDAC 10.13
Mitochondrial residents validated by PCP
    Q7TQ85Ac1164, similar to (in Swiss-Prot “mitochondrial” only by annotation)0.08
    P03996Actin, aortic smooth muscle0.09
    Q9JLG5Brain protein 44-like protein0.01
    XP_216748Coq6 protein, similar to0.08
    XP_227080Elongation factor TU0.20
    XP_341250NipSnap1 protein, similar to0.06
    XP_341644Polymerase (RNA) II polypeptide C, similar to (likely contaminant?)0.20
    XP_217005Protein CGI-51, similar to0.11
    P24142Repressor of estrogen receptor activity (prohibitin)0.08
    Q91V64Tumor-related protein0.20
Likely contaminants
    XP_225259Desmoplakin0.86
    Q6IFV1Keratin complex 1, gene 141.23
    Q63280Keratin type II, cytoskeletal 50.83