Table IV

Selection of interesting non-mitochondrial annotated proteins (based on GO) that were associated with the mitochondrial gene-enriched cluster and that were identified by mass spectrometry (class 2 and class 4 in Supplemental Table S5)

The cluster was enriched in the MS-identified proteins of the “Mito_MS” term (Supplemental Table S5); therefore proteins with unknown localization associated with this cluster may be considered putative mitochondrialor associated with mitochondria. In this table we extracted some of the proteins from Supplemental Table S5 that were identified by mass spectrometry and that were particularly interesting to us (Accession no., Swiss-Prot accession number of the protein corresponding to the gene; Description, gene name; H, heart; S.m., skeletal muscle; columns filled with an asterisk represent differential expression of the gene based on the microarray data; M.pred, Mitopred prediction score of the protein; —, predicted as non-mitochondrial).

Accession #DescriptionHS.m.M.pred
%
Q7TP78 Similar to Aa2-258**100
Q7TQ85 Similar to Ac1164 (in Swiss-Prot “mitochondrial” only by electronic annotation)*100
P05065 Aldolase A**61.50
Q9JLG5 Brain protein 44-like**69.20
P23928 Crystallin, α B chain**99
Q01129 Decorin**
P02692 Fatty acid-binding protein 3**
P04797 Glyceraldehyde-3-phosphate dehydrogenase**
P19804 Nucleoside-diphosphate kinase**
P61016 Phospholamban*69.20
XP_238570 QIL1*99
XP_231617 RIKEN cDNA D130059P03**84.6
XP_341781 RIKEN cDNA 0610042E07*
XP_214074 Similar to myosin light chain 2a*99
P08733 Similar to myosin regulatory light chain 2, ventricular/cardiac muscle     isoform*61.6
XP_215069 Elongation factor TU, EF-Tu (similar to RIKEN cDNA 2300002G02)*92.3