Table II

Significantly altered proteins identified by 2-DE coupled with mass spectrometry

Spot no.Protein nameAverage ratio (T/Ma)Predicted molecular massPredicted pIBiological functionRef.
27Enolase 12.43647.17.01Glycolysis9, 36
43Fructose-bisphosphate aldolase A (ALDA)5.15439.98.49Glycolysis9, 36
70GAPDH31.66836.08.57Glycolysis 36 b
72GAPDH60.40836.08.57Glycolysis 36 b
102GAPDH2.34736.08.57Glycolysis 36 b
103GAPDH2.48736.08.57Glycolysis 36 b
75Malate dehydrogenase, mitochondrial precursor (MDH)2.99635.58.92Tricarboxylic acid cycle 9
76Malate dehydrogenase, mitochondrial precursor (MDH)4.65435.58.92Tricarboxylic acid cycle 9
71TAGLN protein transgelin4.40622.28.41Cytoskeleton/structural9, 10
80Phosphoenolpyruvate carboxykinase, mitochondrial precursor (PEPCK)0.24771.57.56Gluconeogenesis 36 b
78Carbonic anhydrase II (CA2)0.1729.36.87Nitrogen metabolism b
79UGDH0.20855.76.73Glucuronate b
81UDP-glucose pyrophosphorylase 2 (UGP2)0.26655.87.69Glucuronate b
82UDP-glucose pyrophosphorylase 2 (UGP2)0.31455.87.69Glucuronate b
83Aconitate hydratase, mitochondrial precursor0.16386.17.36Tricarboxylic acid cycle b
101Aconitase 20.16486.37.62Tricarboxylic acid cycle b
  • a Tumor versus normal mucosa.

  • b Alteration in CRC reported for the first time.