October 2006
Volume 5Issue 10p1719-2009
Open Access
On the cover, CAX-PAGE/RPLC-MSMS proteomics platform for discovery of protein biomarkers
of traumatic brain injury. Applied to naïve and injured tissue from a controlled cortical
impact rat model, proteins are resolved by multidimensional separations and quantified
by densitometry. Peptide identification and quantitation are then performed and correlated
with protein data. A total of 59 differential proteins were identified. Validation
of subsequent protein hits was performed and correlated to biological function. For
details, see the article by Kobeissy et al., pages 1887–1898....Show more
On the cover, CAX-PAGE/RPLC-MSMS proteomics platform for discovery of protein biomarkers
of traumatic brain injury. Applied to naïve and injured tissue from a controlled cortical
impact rat model, proteins are resolved by multidimensional separations and quantified
by densitometry. Peptide identification and quantitation are then performed and correlated
with protein data. A total of 59 differential proteins were identified. Validation
of subsequent protein hits was performed and correlated to biological function. For
details, see the article by Kobeissy et al., pages 1887–1898.
