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June 2013

Volume 12Issue 6p1489-1751
Open Access
On the cover: Nucleolin (NCL) serves as a scaffolding protein to form miRISC-directed deadenylation complex (DAC) at the 3ʹ -UTR of CSF-1 mRNA. NCL interacts with poly-A+-binding protein C1 (PABPC) and DAC directly as well as with miRISC complex via CSF-1 mRNA 3ʹUTR. We propose that NCL stabilizes the [miRISC-DAC-mRNA] complex and enhances miRISC-directed deadenylation of poly-A+-mRNA. For details, see the article by Ho-Hyung Woo, et al., pages 1661–1667....
On the cover: Nucleolin (NCL) serves as a scaffolding protein to form miRISC-directed deadenylation complex (DAC) at the 3ʹ -UTR of CSF-1 mRNA. NCL interacts with poly-A+-binding protein C1 (PABPC) and DAC directly as well as with miRISC complex via CSF-1 mRNA 3ʹUTR. We propose that NCL stabilizes the [miRISC-DAC-mRNA] complex and enhances miRISC-directed deadenylation of poly-A+-mRNA. For details, see the article by Ho-Hyung Woo, et al., pages 1661–1667.

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