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December 2010

Volume 9Issue 12p2571-2863
Open Access
On the cover: Elucidation of a downstream nuclear PLCβ1 signaling effector in myogenesis. Using a combinational approach of proteomics, immunocytochemistry and molecular biology, we have identified a functional insulin signaling cascade elicited by PLCβ1 in the nucleus. Release of diacylglyscerol (DAG) from phosphoinsositol-4,5-phosphate (PIP2) results in the nuclear activation of PKCβI and subsequent phosphorylation of the eukaryotic elongation factor 1A (eEF1A) on Ser53. For details, see the article by Cocco et al., pages 2719–2728....
On the cover: Elucidation of a downstream nuclear PLCβ1 signaling effector in myogenesis. Using a combinational approach of proteomics, immunocytochemistry and molecular biology, we have identified a functional insulin signaling cascade elicited by PLCβ1 in the nucleus. Release of diacylglyscerol (DAG) from phosphoinsositol-4,5-phosphate (PIP2) results in the nuclear activation of PKCβI and subsequent phosphorylation of the eukaryotic elongation factor 1A (eEF1A) on Ser53. For details, see the article by Cocco et al., pages 2719–2728.

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