January 2007
Volume 6Issue 1p1-171
Open Access
On the cover, an approach for a quantitative comparison of the MHC ligandome and the
transcriptome is shown. From pairs of tumor and autologous normal tissues, both MHC
ligands and mRNA were isolated and quantified. Using the differential N-terminal isotope
coding (dNIC) strategy for modification of MHC bound peptides, several hundred peptide ratios
and sequences were identified. RNA levels were assessed by gene chip analysis and
correlated with their respective peptide presentation ratios. For details, see the
article by Weinzierl et al., pages 102–113....Show more
On the cover, an approach for a quantitative comparison of the MHC ligandome and the
transcriptome is shown. From pairs of tumor and autologous normal tissues, both MHC
ligands and mRNA were isolated and quantified. Using the differential N-terminal isotope
coding (dNIC) strategy for modification of MHC bound peptides, several hundred peptide ratios
and sequences were identified. RNA levels were assessed by gene chip analysis and
correlated with their respective peptide presentation ratios. For details, see the
article by Weinzierl et al., pages 102–113.
