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October 2019

Volume 18Issue 10p1916-2137
Open Access
Stem cell niche in-vivo contains lectins, growth factors and cytokines. We propose one of these recognizes the sulfated glycan, R-10G, on signaling-protein podocalyxin. Sialylated, fucosylated R-10G on a podocalyxin-like glycoprotein on HEVs is the ligand of L- selectin, which, upon ligand-binding, activates lymphocyte migration into lymph nodes. We propose that interactions with carbohydrate- binding proteins are among cues for stem cell survival, maintenance, self-renewal or differentiation. The symbolic nomenclature for monosaccharides is defined in https://www.ncbi.nlm.nih.gov/glycans/snfg.html; the red circle with S is for sulfate; HEV are high endothelial venules. For details see article by Wu et al. pages 1981–2002....
Stem cell niche in-vivo contains lectins, growth factors and cytokines. We propose one of these recognizes the sulfated glycan, R-10G, on signaling-protein podocalyxin. Sialylated, fucosylated R-10G on a podocalyxin-like glycoprotein on HEVs is the ligand of L- selectin, which, upon ligand-binding, activates lymphocyte migration into lymph nodes. We propose that interactions with carbohydrate- binding proteins are among cues for stem cell survival, maintenance, self-renewal or differentiation. The symbolic nomenclature for monosaccharides is defined in https://www.ncbi.nlm.nih.gov/glycans/snfg.html; the red circle with S is for sulfate; HEV are high endothelial venules. For details see article by Wu et al. pages 1981–2002.

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