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September 2007

Volume 6Issue 9p1459-1669
Open Access
On the cover, the in situ proximity ligation assay offers highly specific detection through the requirement for dual recognition and increased sensitivity via a localized DNA amplification reaction. In this paper we have used secondary proximity probes, suitable to detect proximal binding by pairs of mouse and rabbit antibodies, to visualize phosphorylation of platelet-derived growth factor receptor β in cells and tissues at single molecule resolution. For details, see the article by Jarvius et al., pages 1500–1509....
On the cover, the in situ proximity ligation assay offers highly specific detection through the requirement for dual recognition and increased sensitivity via a localized DNA amplification reaction. In this paper we have used secondary proximity probes, suitable to detect proximal binding by pairs of mouse and rabbit antibodies, to visualize phosphorylation of platelet-derived growth factor receptor β in cells and tissues at single molecule resolution. For details, see the article by Jarvius et al., pages 1500–1509.

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