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October 2017

Volume 16Issue 10p1705-1888
Open Access
On the cover: A hypothetical CLASP2 network model in 3T3-L1 adipocytes relative to insulin-stimulated glucose uptake. By performing a series of strategic, successive and confirmatory reciprocal interactome experiments on key novel proteins, we have constructed a 3T3-L1 adipocyte CLASP2 protein network that links CLIP2 to AGAP3, CLASP2 to G2L1, MARK2, and SOGA1, and also led to the identification of SOGA1 as a microtubule-associated protein. Our data supports the hypothesis that CLASP2 proteins are partitioned out to various distinct complexes that are composed of both unique and shared proteins, and each complex possesses the likelihood of being functionally distinct. These results introduce the metabolic function of these proposed novel protein networks and their relationship with microtubules as new fields of cytoskeleton-associated protein biology. For details see the article by Rikke Kruse, et al, pages 1718–1735....
On the cover: A hypothetical CLASP2 network model in 3T3-L1 adipocytes relative to insulin-stimulated glucose uptake. By performing a series of strategic, successive and confirmatory reciprocal interactome experiments on key novel proteins, we have constructed a 3T3-L1 adipocyte CLASP2 protein network that links CLIP2 to AGAP3, CLASP2 to G2L1, MARK2, and SOGA1, and also led to the identification of SOGA1 as a microtubule-associated protein. Our data supports the hypothesis that CLASP2 proteins are partitioned out to various distinct complexes that are composed of both unique and shared proteins, and each complex possesses the likelihood of being functionally distinct. These results introduce the metabolic function of these proposed novel protein networks and their relationship with microtubules as new fields of cytoskeleton-associated protein biology. For details see the article by Rikke Kruse, et al, pages 1718–1735.

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