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May 2017

Volume 16Issue 5p706-958
Open Access
On the cover: DSSO-based in vivo and in vitro cross-linking mass spectrometry (XL-MS) strategies represent new analytical workflows to study protein-protein interactions of large protein assemblies in cells. In combination with EM maps and computational modeling, the architecture of the human 26S proteasome was determined to infer its structural dynamics and regulation. For details, see the article by Xiaorong Wang, et al., pages 840–854....
On the cover: DSSO-based in vivo and in vitro cross-linking mass spectrometry (XL-MS) strategies represent new analytical workflows to study protein-protein interactions of large protein assemblies in cells. In combination with EM maps and computational modeling, the architecture of the human 26S proteasome was determined to infer its structural dynamics and regulation. For details, see the article by Xiaorong Wang, et al., pages 840–854.

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