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December 2009

Volume 8Issue 12p2613-2856
Open Access
On the cover: O-GlcNAc modification of Insulin Receptor Substrate-1 (IRS-1) revealed by ETD-MS/MS. Posttranslational modifications of IRS-1 mediate and modulate the metabolic and mitogenic effects elicited by insulin and IGF-1. O-linked beta-N-acetylglucosamine (O-GlcNAc) modification of IRS-1 occurs in close proximity to protein interaction motifs and thus may provide an additional layer of posttranslational regulation to the highly phosphorylated protein....
On the cover: O-GlcNAc modification of Insulin Receptor Substrate-1 (IRS-1) revealed by ETD-MS/MS. Posttranslational modifications of IRS-1 mediate and modulate the metabolic and mitogenic effects elicited by insulin and IGF-1. O-linked beta-N-acetylglucosamine (O-GlcNAc) modification of IRS-1 occurs in close proximity to protein interaction motifs and thus may provide an additional layer of posttranslational regulation to the highly phosphorylated protein.

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