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July 2020

Volume 19Issue 7p1070-1247
Open Access
The immunopeptidomic analysis shows a predominant of HLA-I bound Asn deamidated peptides arise from the deglycosylated precursors via the ER-associated protein degradation (ERAD) pathway. The Asn deamidated peptides in the peptidome of HLA-I, not in HLA-II or proteolysis, show the N-glycosylation motif. This new insight may provide a potential strategy for predicting deamidation and finding glycoproteins. For details, see the article by Mei et al., pages 1236–1247....
The immunopeptidomic analysis shows a predominant of HLA-I bound Asn deamidated peptides arise from the deglycosylated precursors via the ER-associated protein degradation (ERAD) pathway. The Asn deamidated peptides in the peptidome of HLA-I, not in HLA-II or proteolysis, show the N-glycosylation motif. This new insight may provide a potential strategy for predicting deamidation and finding glycoproteins. For details, see the article by Mei et al., pages 1236–1247.

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