February 2023
Volume 22Issue 2
Open Access
Size exclusion chromatography-coupled mass spectrometry (SEC-MS) to identify global
changes to protein complexes in cancer cells treated with tanespimycin, an inhibitor
of the molecular chaperone Heat Shock Protein 90 (HSP90). Elution profiles for 4,645
proteins in control vs. inhibitor-treated cells were plotted as a heatmap or individual
linegraphs. HSP90 rendered based on PDB structure 6XLB through ‘Illustrate’ program,
from David Goodsell; tanespimycin rendered using MolView software....Show more
Size exclusion chromatography-coupled mass spectrometry (SEC-MS) to identify global
changes to protein complexes in cancer cells treated with tanespimycin, an inhibitor
of the molecular chaperone Heat Shock Protein 90 (HSP90). Elution profiles for 4,645
proteins in control vs. inhibitor-treated cells were plotted as a heatmap or individual
linegraphs. HSP90 rendered based on PDB structure 6XLB through ‘Illustrate’ program,
from David Goodsell; tanespimycin rendered using MolView software.
