interstitial fluids

  • Proteomic Profiling of Paired Interstitial Fluids Reveals Dysregulated Pathways and Salivary NID1 as a Biomarker of Oral Cavity Squamous Cell Carcinoma
    Proteomic Profiling of Paired Interstitial Fluids Reveals Dysregulated Pathways and Salivary NID1 as a Biomarker of Oral Cavity Squamous Cell Carcinoma
    Chia-Wei Hsu, Kai-Ping Chang, Yenlin Huang, Hao-Ping Liu, Pei-Chun Hsueh, Po-Wen Gu, Wei-Chen Yen and Chih-Ching Wu
    Molecular & Cellular Proteomics October 1, 2019, First published on July 17, 2019, 18 (10) 1939-1949; https://doi.org/10.1074/mcp.RA119.001654

    Oral cavity squamous cell carcinoma (OSCC) is frequently diagnosed at an advanced stage, leading to poor prognosis and high mortality rate. To develop method for OSCC detection, proteome of tumor interstitial fluids (TIFs) has been profiled. The proteins differentially expressed in TIFs were highly associated with aminoacyl tRNA biosynthesis pathway. Importantly, nidogen-1 is a potential diagnostic and/or prognostic biomarker. The results suggest that TIF analysis facilitates understanding of OSCC microenvironment and discovery of biomarker candidates.