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Molecular & Cellular Proteomics

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Signal transduction

  • NOTCH Activation Promotes Valve Formation by Regulating the Endocardial Secretome
    You have access
    NOTCH Activation Promotes Valve Formation by Regulating the Endocardial Secretome
    Rebeca Torregrosa-Carrión, Luis Luna-Zurita, Fernando García-Marqués, Gaetano D'Amato, Rebeca Piñeiro-Sabarís, Elena Bonzón-Kulichenko, Jesús Vázquez and José Luis de la Pompa
    Molecular & Cellular Proteomics September 1, 2019, First published on June 27, 2019, 18 (9) 1782-1795; https://doi.org/10.1074/mcp.RA119.001492

    The NOTCH-dependent endocardial secretome has been determined by quantitative MS-based proteomics of mouse embryonic endocardial cells (MEEC). DLL4-mediated NOTCH activation lead to expression of EMT, cytoskeleton and cell-cell/cell-matrix proteins, whereas JAG1-NOTCH signaling activated ECM molecules expression. Data validation in vitro and in vivo support the value of MEEC as a model for studying the endocardial secretome and for the identification of novel factors potentially involved in heart development and disease.

  • You have access
    Proteomic Analysis of NCK1/2 Adaptors Uncovers Paralog-specific Interactions That Reveal a New Role for NCK2 in Cell Abscission During Cytokinesis
    Kévin Jacquet, Sara L. Banerjee, François J. M. Chartier, Sabine Elowe and Nicolas Bisson
    Molecular & Cellular Proteomics October 1, 2018, First published on July 12, 2018, 17 (10) 1979-1990; https://doi.org/10.1074/mcp.RA118.000689
  • You have access
    Universal Plant Phosphoproteomics Workflow and Its Application to Tomato Signaling in Response to Cold Stress*
    Chuan-Chih Hsu, Yingfang Zhu, Justine V. Arrington, Juan Sebastian Paez, Pengcheng Wang, Peipei Zhu, I-Hsuan Chen, Jian-Kang Zhu and W. Andy Tao
    Molecular & Cellular Proteomics October 1, 2018, First published on July 13, 2018, 17 (10) 2068-2080; https://doi.org/10.1074/mcp.TIR118.000702

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